In line with its mandate, the Commission adopts a public health approach in providing a wide range of services to persons infected and affected by HIV, key population, prisons inmate, orphans and vulnerable children and the general population through the community based system and health system.

Broad categories of services provided include HIV Prevention Programme, HIV Testing Services, Treatment, Care and Support Services, Prevention of Mother-To-Child Transmission, Services to People Living with HIV, Home-Based Care, Services to Orphans and Vulnerable Children, Advocacy for Human Rights, Community Systems Strengthening and Health Systems Strengthening.